Enhanced antipyretic activity of new 2, 5-substituted 1, 3, 4-oxadiazoles encapsulated in alginate/gelatin particulated systems

C. Cheptea , V. Şunel , M. Holban , Jacques Desbrieres (1) , M. Popa (2) , C. Lionte

1 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux
2 "Gheorghe Asachi" Technical University of Iaşi - Faculty of Chemical Engineering and Environmental Protection

New 1,3,4-oxadiazoles with pharmacological potential, derived from 5-nitroindazole, have been synthesized. Their chemical structure has been established by elemental and spectral analyses (FT-IR and 1H-NMR). The oxadiazoles presented low toxicity, one compound, either in a free form or loaded in polymeric microcapsules, also showing a remarkable antipyretic activity, similar to that of acetylsalicylic acid.

Domains: Polymers

C. Cheptea, V. Şunel, M. Holban, Jacques Desbrieres, M. Popa, et al.. Enhanced antipyretic activity of new 2, 5-substituted 1, 3, 4-oxadiazoles encapsulated in alginate/gelatin particulated systems. Cellulose Chemistry and Technology, 2012, 46 (1-2), pp.19-25. ⟨hal-01585393⟩