CK2β-regulated signaling controls B cell differentiation and function

Laura Quotti Tubi , Elisa Mandato , Sara Canovas Nunes , Arash Arjomand , Fortunato Zaffino , Sabrina Manni , Alessandro Casellato , Paolo Macaccaro , Nicola Vitulo , Sara Zumerle , Odile Filhol (1) , Brigitte Boldyreff , Christian W Siebel , Antonella Viola , Giorgio Valle , Federica Mainoldi , Stefano Casola , Valeria Cancila , Alessandro Gulino , Claudio Tripodo , Marco Pizzi , Angelo Paolo Dei Tos , Livio Trentin , Gianpietro Semenzato , Francesco Piazza

1 IMAC - Invasion mechanisms in angiogenesis and cancer

frequency in CK2b KO mice suggesting the importance of the b subunit in sustaining antibody affinity maturation. Lastly, since diffuse large B cell lymphoma (DLBCL) cells derive from GC or post-GC B cells and rely on CK2 for their survival, we sought to investigate the consequences of CK2 inhibition on B cell signaling in DLBCL cells. In line with the observations in our murine model, CK2 inactivation leads to signaling defects in pathways that are essential for malignant B-lymphocyte activation.

Mots clés: B lymphocyte B cell development protein kinase CK2 marginal zone germinal center Diffuse large B cell lymphoma B cell receptor signaling; B lymphocyte; B cell development; protein kinase CK2; marginal zone; germinal center; Diffuse large B cell lymphoma; B cell receptor signaling

Domaines: Sciences du Vivant [q-bio]

Laura Quotti Tubi, Elisa Mandato, Sara Canovas Nunes, Arash Arjomand, Fortunato Zaffino, et al.. CK2β-regulated signaling controls B cell differentiation and function. Frontiers in Immunology, 2023, 13, ⟨10.3389/fimmu.2022.959138⟩. ⟨hal-04278900⟩