Oxidative stress suppression in C . elegans by peptides from dogfish skin via regulation of transcription factors DAF-16 and HSF-1 - Archive ouverte HAL Access content directly
Journal Articles Food and Function Year : 2022

Oxidative stress suppression in C . elegans by peptides from dogfish skin via regulation of transcription factors DAF-16 and HSF-1

, , (1) , , , ,
1
Xiaoli Ma
  • Function : Author
Jiao Li
  • Function : Author
Orcun Hacariz
  • Function : Author
Jianguo Xia
  • Function : Author
Benjamin Simpson
  • Function : Author
Zhuanhua Wang
  • Function : Correspondent author
  • PersonId : 1125955

Connectez-vous pour contacter l'auteur

Abstract

Functional peptides were obtained via enzymatic hydrolysis of smooth dogfish (Mustelus canis) skin. The enzyme-assisted process was optimized to achieve high yield of smooth dogfish skin peptides (SDSP). Fractions of SDSP (MW [removed]10 kDa) showed in vitro antioxidant activities. The peptides <2 kDa (SDSP<2 kDa) significantly improved motility, reduced ROS and H2O2 levels of Caenorhabditis elegans, and increased its resistance to oxidative stress compared to the other peptide fractions. In vivo function of SDSP<2 kDa could be explained by their capacity to increase the expression of stress-response genes. The enhanced resistance to oxidative stress mediated by SDSP<2 kDa was dependent on DAF-16 and HSF-1. The amino acid residues and sequences of SDSP<2 kDa were characterized and revealed a higher content of hydrophobic versus polar amino acid contents. This study (especially the in vivo investigation) explored new potent antioxidant peptides derived from dogfish skin
Not file

Dates and versions

hal-03572490 , version 1 (14-02-2022)

Identifiers

Cite

Xiaoli Ma, Jiao Li, Yi Zhang, Orcun Hacariz, Jianguo Xia, et al.. Oxidative stress suppression in C . elegans by peptides from dogfish skin via regulation of transcription factors DAF-16 and HSF-1. Food and Function, 2022, 13 (2), pp.716-724. ⟨10.1039/d1fo02271g⟩. ⟨hal-03572490⟩
11 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More