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Oxidative stress suppression in C . elegans by peptides from dogfish skin via regulation of transcription factors DAF-16 and HSF-1

Abstract : Functional peptides were obtained via enzymatic hydrolysis of smooth dogfish (Mustelus canis) skin. The enzyme-assisted process was optimized to achieve high yield of smooth dogfish skin peptides (SDSP). Fractions of SDSP (MW [removed]10 kDa) showed in vitro antioxidant activities. The peptides <2 kDa (SDSP<2 kDa) significantly improved motility, reduced ROS and H2O2 levels of Caenorhabditis elegans, and increased its resistance to oxidative stress compared to the other peptide fractions. In vivo function of SDSP<2 kDa could be explained by their capacity to increase the expression of stress-response genes. The enhanced resistance to oxidative stress mediated by SDSP<2 kDa was dependent on DAF-16 and HSF-1. The amino acid residues and sequences of SDSP<2 kDa were characterized and revealed a higher content of hydrophobic versus polar amino acid contents. This study (especially the in vivo investigation) explored new potent antioxidant peptides derived from dogfish skin
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Submitted on : Monday, February 14, 2022 - 11:57:00 AM
Last modification on : Tuesday, February 15, 2022 - 3:43:28 AM

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Xiaoli Ma, Jiao Li, Yi Zhang, Orcun Hacariz, Jianguo Xia, et al.. Oxidative stress suppression in C . elegans by peptides from dogfish skin via regulation of transcription factors DAF-16 and HSF-1. Food and Function, Cambridge : Royal Society of Chemistry, 2022, 13 (2), pp.716-724. ⟨10.1039/d1fo02271g⟩. ⟨hal-03572490⟩

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