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Journal articles
Comparative reactivity of medicinal gold( i ) compounds with the cyclic peptide vasopressin and its diselenide analogue
Abstract : The reactions of the medicinal gold(i) compound auranofin and its close analogues with vasopressin and the diselenide analogue were comparatively investigated by LC-electrospray MS/MS. Evidence is gained of the possible cleavage of the S-S and Se-Se bridges induced by Au(i). Notably, we found that, in the absence of reducing agents, the sulfur and selenium atoms are metallated only at high temperature (70 °C) with the preferential binding of gold to selenium. The reaction with the S-S bridge can take place at physiological temperature (37 °C) under reducing conditions. The implications of these results are discussed in the general frame of the reactivity of biologically relevant soft Lewis acids with peptides and proteins.
https://hal-univ-pau.archives-ouvertes.fr/hal-03516255
Contributor : Sylvie Blanc Connect in order to contact the contributor
Submitted on : Friday, January 7, 2022 - 10:10:46 AM
Last modification on : Friday, April 1, 2022 - 3:56:26 AM
Contributor : Sylvie Blanc Connect in order to contact the contributor
Submitted on : Friday, January 7, 2022 - 10:10:46 AM
Last modification on : Friday, April 1, 2022 - 3:56:26 AM