AES and ToF-SIMS combination for single cell chemical imaging of gold nanoparticle-labeled Escherichia coli

Cecile Courreges (1) , Delphine Flahaut (1) , Mélanie Bonnecaze (1) , Sophie Nolivos (1) , Regis. Grimaud (1) , Joachim Allouche (1)

1 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux

A chemical fingerprint of theEscherichia colicell surface labeled by gelatin coated gold nanoparticles was obtained by combining Auger Electron Spectroscopy (AES) for single cell level chemical images, and Time-of-Flight Secondary Ion Mass Spectroscopy (ToF-SIMS) Tandem MS for unambiguous molecular identification of co-localized species.

Domaines: Matériaux; Polymères; Chimie théorique et/ou physique; Chimie analytique

Cecile Courreges, Delphine Flahaut, Mélanie Bonnecaze, Sophie Nolivos, Regis. Grimaud, et al.. AES and ToF-SIMS combination for single cell chemical imaging of gold nanoparticle-labeled Escherichia coli. Chemical Communications, 2021, 57 (44), pp.5446-5449. ⟨10.1039/d1cc01211h⟩. ⟨hal-03265407⟩