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Detection and characterization of biogenic selenium nanoparticles in selenium-rich yeast by single particle ICPMS

Abstract : A method based on single particle inductively coupled plasma mass spectrometry (SP-ICPMS) was developed for the analysis of commercial Se-rich yeasts, to confirm the occurrence of selenium nanoparticles in these food supplements. A considerable reduction of background levels was achieved by combining data acquisition at microsecond dwell times and the use of a H2 reaction cell, improving by a factor of 10 the current state-of-the-art methodology, and bringing size detection limits down to 18 nm for selenium nanoparticles. The presence of nanoparticulate selenium was revealed by size-exclusion chromatography ICPMS, with detection of a selenium peak at the exclusion volume of the column showing absorption at a wavelength corresponding to selenium nanoparticles. SP-ICPMS allowed us to confirm the presence of Se-nanoparticles, as well as to calculate the nanoparticle size distribution, from information about the shape and elemental composition of the nanoparticles obtained by transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDS), respectively. These results reveal the significance of nanoparticles in the speciation of metals and metalloids in biological samples and the capability of SP-ICPMS in combination with TEM-EDS to carry out these analyses.
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https://hal.archives-ouvertes.fr/hal-03133482
Contributor : Ryszard Lobinski <>
Submitted on : Thursday, February 18, 2021 - 11:10:57 AM
Last modification on : Friday, February 19, 2021 - 3:27:56 AM

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Javier Jiménez-Lamana, Isabel Abad-Álvaro, Katarzyna Bierla, Francisco Laborda, Joanna Szpunar, et al.. Detection and characterization of biogenic selenium nanoparticles in selenium-rich yeast by single particle ICPMS. Journal of Analytical Atomic Spectrometry, Royal Society of Chemistry, 2018, 33 (3), pp.452-460. ⟨10.1039/c7ja00378a⟩. ⟨hal-03133482⟩

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