Skip to Main content Skip to Navigation
Journal articles

New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems

Abstract : New grafted copolymers possessing structural units of 1-vinyl-3-(1-carboxymethyl) imidazolium betaine were obtained by graft copolymerization of N-vinylimidazole onto gellan gum followed by the polymer-analogous reactions on grafted polymer with the highest grafting percentage using sodium chloroacetate as the betainization agent. The grafted copolymers were prepared using ammonium persulfate/N,N,N',N' tetramethylethylenediamine in a nitrogen atmosphere. The grafting reaction conditions were optimized by changing one of the following reaction parameters: initiator concentration, monomer concentration, polymer concentration, reaction time or temperature, while the other parameters remained constant. The highest grafting yield was obtained under the following reaction conditions: ci = 0.08 mol/L, cm = 0.8 mol/L, cp = 8 g/L, tr = 4 h and T = 50 °C. The kinetics of the graft copolymerization of N-vinylimidazole onto gellan was discussed and a suitable reaction mechanism was proposed. The evidence of the grafting reaction was confirmed through FTIR spectroscopy, X-ray diffraction, 1H-NMR spectroscopy and scanning electron microscopy. The grafted copolymer with betaine structure was obtained by a nucleophilic substitution reaction where the betainization agent was sodium chloroacetate. Preliminary results prove the ability of the grafted copolymers to bind amphoteric drugs (cefotaxime) and, therefore, the possibility of developing the new sustained drug release systems.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-pau.archives-ouvertes.fr/hal-03043282
Contributor : Hal Iprem <>
Submitted on : Monday, December 7, 2020 - 11:21:32 AM
Last modification on : Friday, January 15, 2021 - 9:21:03 AM

File

molecules-25-05451-v2.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Stefania Racovita, Nicolae Baranov, Ana Macsim, Catalina Lionte, Corina Cheptea, et al.. New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems. Molecules, MDPI, 2020, 25 (22), ⟨10.3390/molecules25225451⟩. ⟨hal-03043282⟩

Share

Metrics

Record views

33

Files downloads

21