membranes Cu Homeostasis in Bacteria: The Ins and Outs - Université de Pau et des Pays de l'Adour Accéder directement au contenu
Article Dans Une Revue Membranes Année : 2020

membranes Cu Homeostasis in Bacteria: The Ins and Outs

Résumé

Copper (Cu) is an essential trace element for all living organisms and used as cofactor in key enzymes of important biological processes, such as aerobic respiration or superoxide dismutation. However, due to its toxicity, cells have developed elaborate mechanisms for Cu homeostasis, which balance Cu supply for cuproprotein biogenesis with the need to remove excess Cu. This review summarizes our current knowledge on bacterial Cu homeostasis with a focus on Gram-negative bacteria and describes the multiple strategies that bacteria use for uptake, storage and export of Cu. We furthermore describe general mechanistic principles that aid the bacterial response to toxic Cu concentrations and illustrate dedicated Cu relay systems that facilitate Cu delivery for cuproenzyme biogenesis. Progress in understanding how bacteria avoid Cu poisoning while maintaining a certain Cu quota for cell proliferation is of particular importance for microbial pathogens because Cu is utilized by the host immune system for attenuating pathogen survival in host cells.
Fichier principal
Vignette du fichier
membranes-10-00242-v2.pdf (4.4 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02950711 , version 1 (28-09-2020)

Identifiants

Citer

Andreea Andrei, Yavuz Öztürk, B.K. Hassani, Juna Rauch, Dorian Marckmann, et al.. membranes Cu Homeostasis in Bacteria: The Ins and Outs. Membranes, 2020, 10 (9), pp.1-45. ⟨10.3390/membranes10090242⟩. ⟨hal-02950711⟩
38 Consultations
124 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More