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Coupling of an atmospheric pressure microplasma ionization source with an Orbitrap Fusion Lumos Tribrid 1M mass analyzer for ultra-high resolution isotopic analysis of uranium

Abstract : The coupling of a combined atomic and molecular (CAM) ionization source, the liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma to an Orbitrap Fusion Lumos Tribrid 1M mass spectrometer is described as a significant step towards the elimination of isobaric interferences in elemental/isotopic mass spectrometry. The developed setup permits broadband, elemental mass spectra to be easily acquired at a mass resolution (m/Δm) of 500 000. A new ion source housing and integrated control system provide enhanced stability and sensitivity of the microplasma ion source in comparison to the previous designs. Detailed evaluation of the ion sampling parameters provided insight into differences with other Orbitrap platforms leading to a 5-fold increase in resolution in elemental/isotopic analysis. The roles of data acquisition/ion processing parameters were evaluated with regards to the precision and accuracy of 235U/238U isotope ratios. Significantly, the precision of those measurements improves as a function of pre-set mass resolution up to a value of 1 000 000, where a precision of 0.086% RSD is obtained for uranium concentrations of 100 ng mL−1. Analytical response curves (log–log), acquired for the two uranium isotopes at a resolution of 120 000 were linear (R2 = 0.9969) over more than 5 orders of magnitude, with limits of detection of 1 pg mL−1 for U. Based on 60 μL injection volumes, this represents a mass of 70 fg 235U. These figures of merit satisfy International Target Values (ITVs) for Measurement Uncertainties in Safeguarding Nuclear Materials set by the International Atomic Energy Agency (IAEA). Ultimately, and totally unique from beam-type instruments, the move to the higher-resolution Orbitrap platform provides all of the benefits of high mass resolution, with no penalties in sensitivity, precision, or dynamic range for uranium analysis.
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https://hal-univ-pau.archives-ouvertes.fr/hal-02320538
Contributor : Sylvie Blanc <>
Submitted on : Friday, October 18, 2019 - 6:51:41 PM
Last modification on : Wednesday, March 4, 2020 - 1:47:00 AM

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Edward Hoegg, Simon Godin, Joanna Szpunar, Ryszard Lobinski, David w. Koppenaal, et al.. Coupling of an atmospheric pressure microplasma ionization source with an Orbitrap Fusion Lumos Tribrid 1M mass analyzer for ultra-high resolution isotopic analysis of uranium. Journal of Analytical Atomic Spectrometry, Royal Society of Chemistry, 2019, 34 (7), pp.1387-1395. ⟨10.1039/C9JA00154A⟩. ⟨hal-02320538⟩

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