Skip to Main content Skip to Navigation
Journal articles

Inhibitory effect of metals on animal and plant glutathione transferases

Abstract : Glutathione transferases (GSTs) represent a widespread enzyme superfamily in eukaryotes and prokaryotes catalyzing different reactions with endogenous and xenobiotic substrates such as organic pollutants. The latter are often found together with metal contamination in the environment. Besides performing of essential functions, GSTs protect cells by conjugation of glutathione with various reactive electrophiles. The interference of toxic metals with this functionality of GSTs may have unpredictable toxicological consequences for the organisms. In this review results from the recent literature are summarized and discussed describing the ability of metals to inhibit intracellular detoxification processes in animals and plants.
Complete list of metadata
Contributor : Sylvie Blanc Connect in order to contact the contributor
Submitted on : Wednesday, December 9, 2020 - 6:19:41 PM
Last modification on : Sunday, June 26, 2022 - 3:00:31 AM
Long-term archiving on: : Wednesday, March 10, 2021 - 7:57:54 PM


Dobritzsch et al_JTEMB.pdf
Files produced by the author(s)




Dirk Dobritzsch, Konstantin Grancharov, Corinna Hermsen, Gerd-Joachim Krauss, Dirk Schaumlöffel. Inhibitory effect of metals on animal and plant glutathione transferases. Journal of Trace Elements in Medicine and Biology, Elsevier, 2020, 57, pp.48-56. ⟨10.1016/j.jtemb.2019.09.007⟩. ⟨hal-02300965⟩



Record views


Files downloads