Inhibitory effect of metals on animal and plant glutathione transferases - Archive ouverte HAL Access content directly
Journal Articles Journal of Trace Elements in Medicine and Biology Year : 2020

Inhibitory effect of metals on animal and plant glutathione transferases

, , , , (1)
1

Abstract

Glutathione transferases (GSTs) represent a widespread enzyme superfamily in eukaryotes and prokaryotes catalyzing different reactions with endogenous and xenobiotic substrates such as organic pollutants. The latter are often found together with metal contamination in the environment. Besides performing of essential functions, GSTs protect cells by conjugation of glutathione with various reactive electrophiles. The interference of toxic metals with this functionality of GSTs may have unpredictable toxicological consequences for the organisms. In this review results from the recent literature are summarized and discussed describing the ability of metals to inhibit intracellular detoxification processes in animals and plants.
Fichier principal
Vignette du fichier
Dobritzsch et al_JTEMB.pdf (1.35 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-02300965 , version 1 (09-12-2020)

Identifiers

Cite

Dirk Dobritzsch, Konstantin Grancharov, Corinna Hermsen, Gerd-Joachim Krauss, Dirk Schaumlöffel. Inhibitory effect of metals on animal and plant glutathione transferases. Journal of Trace Elements in Medicine and Biology, 2020, 57, pp.48-56. ⟨10.1016/j.jtemb.2019.09.007⟩. ⟨hal-02300965⟩
133 View
306 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More