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Inhibitory effect of metals on animal and plant glutathione transferases

Abstract : Glutathione transferases (GSTs) represent a widespread enzyme superfamily in eukaryotes and prokaryotes catalyzing different reactions with endogenous and xenobiotic substrates such as organic pollutants. The latter are often found together with metal contamination in the environment. Besides performing of essential functions, GSTs protect cells by conjugation of glutathione with various reactive electrophiles. The interference of toxic metals with this functionality of GSTs may have unpredictable toxicological consequences for the organisms. In this review results from the recent literature are summarized and discussed describing the ability of metals to inhibit intracellular detoxification processes in animals and plants.
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https://hal-univ-pau.archives-ouvertes.fr/hal-02300965
Contributor : Sylvie Blanc <>
Submitted on : Monday, September 30, 2019 - 9:46:54 AM
Last modification on : Thursday, March 5, 2020 - 7:17:44 PM

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Dirk Dobritzsch, Konstantin Grancharov, Corinna Hermsen, Gerd-Joachim Krauss, Dirk Schaumlöffel. Inhibitory effect of metals on animal and plant glutathione transferases. Journal of Trace Elements in Medicine and Biology, Elsevier, 2020, 57, pp.48-56. ⟨10.1016/j.jtemb.2019.09.007⟩. ⟨hal-02300965⟩

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