Synthesis and biological activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds containing a phenylalanine moiety

M. Moise , V. Sunel , L. Profire , M. Popa (1) , Jacques Desbrieres (2) , C. Peptu

1 Department of Computer Science
2 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux

New 1,3,4-thiadiazole, 6, 7 and 1,2,4-triazole derivatives, 8, 9 containing a phenylalanine moiety have been synthesized by intramolecular cyclization of 1,4- disubstituted thiosemicarbazides, 4, 5, in acid and alkaline media, respectively; the thiosemicarbazides were obtained by reaction of hydrazide 3 with appropriate aromatic isothiocyanates. The toxicity of the synthesized compounds was evaluated and the antiinflammatory study of the triazole compound 9 established an appreciable antiinflammatory activity that is comparable with that of other nonsteroidal anti-inflammatory agents. © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

Domaines: Polymères

M. Moise, V. Sunel, L. Profire, M. Popa, Jacques Desbrieres, et al.. Synthesis and biological activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds containing a phenylalanine moiety. Molecules, 2009, 14 (7), pp.2621-2631. ⟨10.3390/molecules14072621⟩. ⟨hal-01585412⟩