Synthesis of poly(aspartimide)-based bio-glycoconjugates

I. Carlescu , H.M.I. Osborn , Jacques Desbrieres (1) , D. Scutaru , M. Popa (2)

1 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux
2 "Gheorghe Asachi" Technical University of Iaşi - Faculty of Chemical Engineering and Environmental Protection

The purpose of this programme was to synthesize and analyze new bioconjugates of interest for the potential inhibition of the influenza virus, using poly(aspartimide) as a polymer support. The macromolecular targets were obtained by attaching various sialic acid-linker-amine compounds to poly(aspartimide). 1H and 13C NMR studies were then performed to analyze the degree of incorporation of the sialic acid-linker-amine compounds within the poly(aspartimide). These studies illustrated that the incorporation was dependent on the nature of the spacer between the sugar and the amine functionality. Thus aliphatic spacers favoured the inclusion of sialic acid onto the polymer support whereas compounds having only an aromatic moiety between the sialic acid and the amine could not be easily incorporated. © 2009 Elsevier Ltd.

Domaines: Polymères

I. Carlescu, H.M.I. Osborn, Jacques Desbrieres, D. Scutaru, M. Popa. Synthesis of poly(aspartimide)-based bio-glycoconjugates. Carbohydrate Research, 2010, 345 (1), pp.33-40. ⟨10.1016/j.carres.2009.08.034⟩. ⟨hal-01585407⟩