Novel acyl derivatives of n-(p-aminobenzoyl)-l-glutamine encapsulated in polymeric nanocapsules with potential antitumoral activity
Résumé
New compounds with antitumoral activity have been obtained, by synthesizing aminoacid derivatives with formyl or acetyl groups grafted on N-(p-aminobenzoyl)-L-glutaminc. The suggested chemical structure of the new compounds was confirmed by elemental and spectral analysis (FT-IR and 1H-NMR). The synthesized acyl derivatives have been encapsulated into polymeric nanocapsules, based on chitosan and sodium alginate. Similarly to a reference cytostatic drug (methotrexate), biological tests showed that all compounds and all loaded nanocapsules presented low toxicity and good antitumoral activity against Erlich ascetic tumour in mice.