Synthesis and characterization of new heterocyclic compounds with potential antituberculosis activity and their immobilization on polymer supports

R. Aparaschivei , M. Holban , V. Sunel , M. Popa (1) , Jacques Desbrieres (2)

1 "Gheorghe Asachi" Technical University of Iaşi - Faculty of Chemical Engineering and Environmental Protection
2 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux

New biologically active compounds, obtained by synthesizing new hydrazides derived from benzoxazolyl-2mercaptoformic acid, respectively benzoxazolyl-2-mercaptoacetic acid, have been chemically immobilized onto poly(maleic anhydride-alt-vinyl acetate) supports, forming drug-polymer conjugates with controlled delivery. The reaction products were characterized by elemental and spectral analyses (FT-IR, 1H-NMR). Toxicological and tuberculostatic activity tests recommend certain reaction products as therapeutic candidates with pharmacological application.

Domaines: Polymères

R. Aparaschivei, M. Holban, V. Sunel, M. Popa, Jacques Desbrieres. Synthesis and characterization of new heterocyclic compounds with potential antituberculosis activity and their immobilization on polymer supports. Cellulose Chemistry and Technology, 2012, 46 (5-6), pp.301-306. ⟨hal-01585396⟩