Drug-Polymer Conjugates with Tuberculostatic Activity, Based on Poly (N-Vinyl Pyrrolidone-alt-Itaconic Anhydride) and Novel Aminoacid Hydrazides

D. Grebinişan , M.N. Holban , C. Lionte , C. Peptu , V. Şunel , M. Popa (1) , Jacques Desbrieres (2)

1 "Gheorghe Asachi" Technical University of Iaşi - Faculty of Chemical Engineering and Environmental Protection
2 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux

Novel drug-polymer conjugates were prepared by chemical immobilization of hydrazides on poly (N-vinyl pyrrolidone-alt-itaconic anhydride) support. Hydrazides with tuberculostatic activity were synthesized as derivatives of N-(p-nitrobenzoyl)-L-glutamine. Elemental and spectral analysis confirmed the chemical structure of the newly synthesized compounds and the evaluation of biological activity showed an increase of the tuberculostatic effect and a lower toxicity by chemically linking the hydrazides onto co-polymer. © 2013 Copyright Taylor and Francis Group, LLC.

Domaines: Polymères

D. Grebinişan, M.N. Holban, C. Lionte, C. Peptu, V. Şunel, et al.. Drug-Polymer Conjugates with Tuberculostatic Activity, Based on Poly (N-Vinyl Pyrrolidone-alt-Itaconic Anhydride) and Novel Aminoacid Hydrazides. Polymer - Plastics Technology and Engineering, 2013, 52 (12), pp.1213-1219. ⟨10.1080/03602559.2013.798824⟩. ⟨hal-01585390⟩