Sulfonic Derivatives of 2-Mercaptobenzoxazole and Its Conjugates with Poly(Maleic anhydride-alt-vinyl acetate) with Potential Pharmacological Applications
Résumé
The results reported represent a continuation of the research on the synthesis of new 2-mercaptobenzoxazole derivatives with potential pharmacological activity and corresponding conjugates prepared by chemical immobilization through ester and amidic bonds onto poly(maleic anhydride-alt-vinyl acetate). New sulfonic compounds derived from 2-mercaptobenzoxazole were synthesized in order to obtain substances with a nucleophilic capacity. Their immobilization on copolymer support, based on poly(maleic anhydride-alt-vinyl acetate) through ester or amidic bonds led to polymer—biologically active principle conjugates with controlled release capacity. Release of the compound immobilized by ester bonds was found to take place in the first 5–6 h. The 2-mercaptobenzoxazole derivatives and the conjugates were characterized using elemental and spectral analysis (FT-IR, 1H-NMR). Toxicological and antimicrobial tests were performed, recommending some of these therapeutics as candidates for pharmacological applications.