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Exposition professionnelle Toxicokinetics Cigarette smoke Environmental risk factors Bretagne Hypertension artérielle pulmonaire Camp NF-κB Diesel exhaust particles Nrf2 Hepatocyte Granulocyte-macrophage colony-stimulating factor Cytochrome P450 Chest tube drainage Inflammatory diseases Toxicité Inorganic arsenic Dendritic cells Cytokines Risque professionnel Interstitial lung disease Idiopathic pulmonary fibrosis Ruxolitinib Human hepatocytes Inflammation Polycyclic aromatic hydrocarbon Immunotoxicity Arsenic Cardiovascular diseases Immunité Carcinogens Polarization Efferocytosis Bactérie Fibrose pulmonaire Benzoapyrene COPD Pneumopathie infiltrante diffuse Hepatoma Systemic sclerosis Cytochrome P-450 In vitro Toxicity GM-CSF Eleveurs de bétail Pulmonary arterial hypertension Cardiovascular Farmer Drug transporters Bisphenol A Stress Oxidative stress Hepatocytes Apoptosis Nintedanib Inhibition Bacteria Lung Diesel exhaust Lait Infection France AhR Cancer Cancer du pancréas Pesticides Regulation Heterocyclic amines HepaRG cells Epidemiology Air pollution Polycyclic aromatic hydrocarbons Bronchopneumopathie chronique obstructive Detoxification Docking Comorbidity Interleukins Macrophages Immunity Drug transporter Dairy farmers Scleroderma Macrophage Whole lung lavage Humans Dust exposure Cell signaling Aryl hydrocarbon receptor Drug-drug interactions Gene expression Genotoxicity Cytokine Interleukin-8 Chronic obstructive pulmonary disease Drug–drug interactions Crystalline silica Pharmacokinetics Chest tube Calcium Differentiation