Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Mechanical Frequency Tuning by Sensory Hair Cells, the Receptors and Amplifiers of the Inner Ear

Abstract : We recognize sounds by analyzing their frequency content. Different frequency components evoke distinct mechanical waves that each travel within the hearing organ, or cochlea, to a frequency-specific place. These signals are detected by hair cells, the ear's sensory receptors, in response to vibrations of mechanically sensitive antennas termed hair bundles. An active process enhances the sensitivity, sharpens the frequency tuning, and broadens the dynamic range of hair cells through several mechanisms, including active hair-bundle motility. A dynamic interplay between negative stiffness mediated by ion channels' gating forces and delayed force feedback owing to myosin motors and channel reclosure by calcium ions brings the hair bundle to the vicinity of an oscillatory instability-a Hopf bifurcation. Operation near a Hopf bifurcation provides nonlinear generic features that are characteristic of hearing. Multiple gradients at molecular, cellular, and supercellular scales tune hair cells to characteristic frequencies that cover our auditory range.
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-03036747
Contributeur : Pascal Martin <>
Soumis le : mercredi 16 décembre 2020 - 14:12:16
Dernière modification le : lundi 8 février 2021 - 17:12:04

Fichier

MH-30ePMc_ForHAL.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Pascal Martin, A.J. Hudspeth. Mechanical Frequency Tuning by Sensory Hair Cells, the Receptors and Amplifiers of the Inner Ear. Annual Review of Condensed Matter Physics, Annual Reviews 2021, 12 (1), ⟨10.1146/annurev-conmatphys-061020-053041⟩. ⟨hal-03036747⟩

Partager

Métriques

Consultations de la notice

78

Téléchargements de fichiers

20