ARID2 Chromatin Remodeler in Hepatocellular Carcinoma

Robin Loesch (1) , Linda Chenane (1) , Sabine Colnot (1)

1 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers

Chromatin remodelers are found highly mutated in cancer including hepatocellular carcinoma. These mutations frequently occur in ARID (AT-rich Interactive Domain) genes, encoding subunits of the ATP-dependent SWI/SNF remodelers. The increasingly prevalent complexity that surrounds the functions and specificities of the highly modular BAF (BG1/BRM-associated factors) and PBAF (polybromo-associated BAF) complexes, including ARID1A/B or ARID2, is baffling. The involvement of the SWI/SNF complexes in diverse tissues and processes, and especially in the regulation of gene expression, multiplies the specific outcomes of specific gene alterations. A better understanding of the molecular consequences of specific mutations impairing chromatin remodelers is needed. In this review, we summarize what we know about the tumor-modulating properties of ARID2 in hepatocellular carcinoma.

Mots clés: ARID2; SWI/SNF; cancer; chromatin; hepatocellular carcinoma

Domaines: Sciences du Vivant [q-bio]

Robin Loesch, Linda Chenane, Sabine Colnot. ARID2 Chromatin Remodeler in Hepatocellular Carcinoma. Cells, 2020, 9 (10), pp.2152. ⟨10.3390/cells9102152⟩. ⟨hal-03007683⟩